Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->
نویسندگان
چکیده
Two new compounds, named lyciumlignan D (1) and lyciumphenyl propanoid A (2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3-9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.
منابع مشابه
Hepatoprotective pyrrole derivatives of Lycium chinense fruits.
As a part of our search for hepatoprotective compounds from Lycium chinense fruits, three new pyrrole derivatives (1-3) were isolated. These compounds and a related synthetic methylated compound (4) were evaluated for their biological activity and structure-activity relationship, and compounds 1 and 2 showed hepatoprotective effects comparable to silybin at the concentration of 0.1 microM (64.4...
متن کاملAnti-Ulcerogenic Properties of Lycium chinense Mill Extracts against Ethanol-Induced Acute Gastric Lesion in Animal Models and Its Active Constituents.
The objective of this study was to explore the gastroprotective properties of the aerial part of Lycium chinense Mill (LCA) against ethanol-induced gastric mucosa lesions in mice models. Administration of LCA at doses of 50, 100, 200 and 400 mg/kg body weight prior to ethanol consumption dose dependently inhibited gastric ulcers. The gastric mucosal injury was analyzed by gastric juice acidity,...
متن کاملNine new compounds from the root bark of Lycium chinense and their α-glucosidase inhibitory activity
State Key Laboratory of Bioactive Substance a of Materia Medica, Chinese Academy of Medic Beijing 100050, People's Republic of China. E State Key Laboratory Breeding Base of Da Chinese Materia Medica, China Academy 100700, People's Republic of China † Electronic supplementary information (E IR, and ECD spectra. See DOI: 10.1039/c6 ‡ These authors contributed equally. Cite this: RSC Adv., 2017, ...
متن کاملGoji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity.
Since the beginning of this century, Goji berries and juice are being sold as health food products in western countries and praised in advertisements and in the media for well-being and as an anti-aging remedy. The popularity of Goji products has rapidly grown over the last years thanks to efficient marketing strategies. Goji is a relatively new name given to Lycium barbarum and L. chinense, tw...
متن کاملAntioxidant Potential of Root Bark of Berberis Lycium Royle. from Galliyat, Western Himalaya, Pakistan
This study was to compare the relative level of antioxidant activity of methanolic extract of root bark of Berberis lycium Royle., in different test systems of antioxidant determination i.e ABTS (2,2’-azinobis-(3-ethyl-benzothiazoline-6-sulfonic acid) radical cation assay, Phosphomolybdenum assay and reducing power assay. In all these assays the antioxidant activity of extract was compared to t...
متن کامل